Joseph S Warmus: search on Z-Library

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1

Small Molecule Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

Londregan, Allyn Timothy, Wei, Liuqing, Xiao, Jun, Lintner, Nathanael G, Petersen, Donna N., Dullea, Robert, Mcclure, Kim F., Bolt, Michael W, Warmus, Joseph S, Coffey, Steven B., Limberakis, Chris, G

Journal:

Journal of Medicinal Chemistry

Year:

2018

Language:

english

File:

PDF, 1000 KB

english, 2018

2

ChemInform Abstract: An Improved Amide Coupling Procedure for the Synthesis of N-(Pyridin-2-yl)amides.

Allyn T. Londregan, Gregory Storer, Ceshea Wooten, Xiaojing Yang, Joseph Warmus

Journal:

Year:

2009

File:

PDF, 23 KB

2009

3

Chiral lithio formamidines. Are they configurationally stable?

A.I. Meyers, Joseph Guiles, Joseph S. Warmus, Michael A. Gonzalez

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 249 KB

english, 1991

4

Chiral formamidines. Asymmetric synthesis of 1,1-disubstituted tetrahydroisoquinolines.

A.I. Meyers, Michael A. Gonzalez, Vladimir Struzka, Atsushi Akahane, Joseph Guiles, Joseph S. Warmus

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 216 KB

english, 1991

5

Chiral formamidines. The mechanism of mono- and di-alkylation leading to chiral, non-racemic tetrahydroisoquinolines.

A.I. Meyers, Joseph S. Warmus, Michael A. Gonzalez, Joseph Guiles, Atsushi Akahane

Journal:

Tetrahedron Letters

Year:

1991

Language:

english

File:

PDF, 225 KB

english, 1991

6

Synthesis and transannular diels-alder reactions of (E,E,E)-cyclotetradeca-2,8,10-trienones

William R. Roush, Joseph S. Warmus, Andrea B. Works

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 272 KB

english, 1993

7

Discovery and SAR of benzyl phenyl ethers as inhibitors of bacterial phenylalanyl-tRNA synthetase

Justin I. Montgomery, Peter L. Toogood, Kim M. Hutchings, Jia Liu, Lakshmi Narasimhan, Timothy Braden, Michael R. Dermyer, Angela D. Kulynych, Yvonne D. Smith, Joseph S. Warmus, Clarke Taylor

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 224 KB

english, 2009

8

2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang, Stephen Barrett, Alexander Bridges, Huifen Chen, Richard Gowan, Michael Kaufman, Judy Sebolt-Leopold, Wilbur Leopold, Ronald Merriman, Jeffrey Ohren, Al

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 252 KB

english, 2008

9

Erratum to “2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase)” [Bioorg. Med. Chem. Lett. 18 (2008) 6171]

Joseph S. Warmus, Cathlin Flamme, Lu Yan Zhang, Stephen Barrett, Alexander Bridges, Huifen Chen, Richard Gowan, Michael Kaufman, Judy Sebolt-Leopold, Wilbur Leopold, Ronald Merriman, Jeffrey Ohren, Al

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2009

Language:

english

File:

PDF, 106 KB

english, 2009

10

Inhibition of interleukin-1β converting enzyme (ICE or caspase 1) by aspartyl acyloxyalkyl ketones and aspartyl amidooxyalkyl ketones

Paul Galatsis, Bradley Caprathe, Dennis Downing, John Gilmore, William Harter, Sheryl Hays, Catherine Kostlan, Kristin Linn, Elizabeth Lunney, Kim Para, Anthony Thomas, Joseph Warmus, Hamish Allen, Ke

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 2.63 MB

english, 2010

11

The enantioselective synthesis of (R)- and (S)-3-amino-3,4-dihydro-1H-[1,8]naphthyridin-2-one

Allyn T. Londregan, David Bernhardson, James Bradow, Teresa M. Makowski, Gregory Storer, Joseph Warmus, Ceshea Wooten, Xiaojing Yang

Journal:

Tetrahedron: Asymmetry

Year:

2010

Language:

english

File:

PDF, 379 KB

english, 2010

12

An improved amide coupling procedure for the synthesis of N-(pyridin-2-yl)amides

Allyn T. Londregan, Gregory Storer, Ceshea Wooten, Xiaojing Yang, Joseph Warmus

Journal:

Tetrahedron Letters

Year:

2009

Language:

english

File:

PDF, 1.04 MB

english, 2009

13

Synthesis and Diels-Alder reactions of 2-alkyl-5-methylene-1,3-dioxolan-4-ones and 2-alkyl-3-acyl-5-methylene-1,3-oxazolidin-4-ones: Highly exo and diastereoface selective chiral ketene equivalents

William R. Roush, Amy P. Essenfeld, Joseph S. Warmus, Bradley B. Brown

Journal:

Tetrahedron Letters

Year:

1989

Language:

english

File:

PDF, 284 KB

english, 1989

14

Effect of dienophile activating group on the stereoselectivity of the intramolecular diels-alder reaction

William R Roush, Amy P Essenfeld, Joseph S Warmus

Journal:

Tetrahedron Letters

Year:

1987

Language:

english

File:

PDF, 276 KB

english, 1987

15

A reinvestigation of the reported synthesis of the spirobenzyl isoquinoline alkaloid, iso-ochotensine

A.I Meyers, Atsushi Akahane, Vladimir Struzka, Joseph S Warmus, Michael Gonzalez, Guy Milot

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 175 KB

english, 1997

16

Rapid optimization of an ice inhibitor synthesis using multiple reaction conditions in a parallel array

Joseph S. Warmus, Todd R. Ryder, John C. Hodges, Robert M. Kennedy, Kenneth D. Brady

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 376 KB

english, 1998

17

Enantioselective synthesis of the bottom half of chlorothricolide. 3. Studies of the steric directing group strategy for stereocontrol in intramolecular Diels-Alder reactions

Roush, William R., Kageyama, Masanori, Riva, Renata, Brown, Bradley B., Warmus, Joseph S., Moriarty, Kevin J.

Journal:

Journal of Organic Chemistry

Year:

1991

Language:

english

File:

PDF, 3.52 MB

english, 1991

18

ChemInform Abstract: Synthesis of 2,6-Disubstituted-7,8-dihydro-6H-pyrano[2,3-6]pyrazines.

Jian-Cheng Li, Michael Munchhof, Joseph S. Warmus, Paul D. Bonin, Kim F. McClure

Journal:

Year:

2012

File:

PDF, 28 KB

2012

19

Structure based design of an in vivo active hydroxamic acid inhibitor of P. aeruginosa LpxC

Joseph S. Warmus, Cheryl L. Quinn, Clarke Taylor, Sean T. Murphy, Timothy A. Johnson, Chris Limberakis, Daniel Ortwine, Joel Bronstein, Paul Pagano, John D. Knafels, Sandra Lightle, Igor Mochalkin, Ro

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2012

Language:

english

File:

PDF, 2.17 MB

english, 2012

20

Synthesis of 2,6-disubstituted-7,8-dihydro-6H-pyrano[2,3-6]pyrazines

Jian-Cheng Li, Michael Munchhof, Joseph S. Warmus, Paul D. Bonin, Kim F. McClure

Journal:

Tetrahedron Letters

Year:

2012

Language:

english

File:

PDF, 193 KB

english, 2012

21

Integrating combinatorial chemistry into the discovery pipeline

Joseph S Warmus

Journal:

Drug Discovery Today

Year:

1999

Language:

english

File:

PDF, 106 KB

english, 1999

22

Discovery of 5-phenoxy-1,3-dimethyl-1H-pyrazole-4-carboxamides as potent agonists of TGR5 via sequential combinatorial libraries

Londregan, Allyn T., Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Boehm, Markus, Carpino, Philip A., Chin, Janice E., Janssen, Ann M., Roush, Nicole S., Buxton, Joanne, Hinchey, Terri

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 947 KB

english, 2013

23

A Novel Nonpeptide HIV-1 Protease Inhibitor: Elucidation of the Binding Mode and Its Application in the Design of Related Analogs

Lunney, Elizabeth A., Hagen, Susan E., Domagala, John M., Humblet, Christine, Kosinski, Janet, Tait, Bradley D., Warmus, Joseph S., Wilson, Michael, Ferguson, Donna

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 5.17 MB

english, 1994

24

Identification of Tetrahydropyrido[4,3- d ]pyrimidine Amides as a New Class of Orally Bioavailable TGR5 Agonists

Piotrowski, David W., Futatsugi, Kentaro, Warmus, Joseph S., Orr, Suvi T. M., Freeman-Cook, Kevin D., Londregan, Allyn T., Wei, Liuqing, Jennings, Sandra M., Herr, Michael, Coffey, Steven B., Jiao, We

Journal:

ACS Medicinal Chemistry Letters

Year:

2013

Language:

english

File:

PDF, 370 KB

english, 2013

25

Encyclopedia of Reagents for Organic Synthesis || 4-Iodo-2-trimethylstannyl-1-butene

Warmus, Joseph S.

Year:

2001

Language:

english

File:

PDF, 75 KB

english, 2001

26

Encyclopedia of Reagents for Organic Synthesis || 5-Chloro-2-trimethylstannyl-1-pentene

Warmus, Joseph S.

Year:

2001

Language:

english

File:

PDF, 60 KB

english, 2001

27

Encyclopedia of Reagents for Organic Synthesis || ( Z )-5-Chloro-3-trimethylstannyl-2-pentene

Warmus, Joseph S.

Year:

2001

Language:

english

File:

PDF, 54 KB

english, 2001

28

Diastereoselective Synthesis of β-Heteroaryl syn -α-Methyl-β-Amino Acid Derivatives via a Double Chiral Auxiliary Approach

Bian, Jianwei, Blakemore, David, Warmus, Joseph S., Sun, Jianmin, Corbett, Matthew, Rose, Colin R., Bechle, Bruce M.

Journal:

Organic Letters

Year:

2013

Language:

english

File:

PDF, 782 KB

english, 2013

29

Polyaromatic Scavenger Reagents (PAHSR): A New Methodology for Rapid Purification in Solution-Phase Combinatorial Synthesis

Warmus, Joseph S., da Silva, Marianne I.

Journal:

Organic Letters

Year:

2000

Language:

english

File:

PDF, 93 KB

english, 2000

30

A modified procedure for the preparation of 2,5-dihydropyrrole (3-pyrroline)

Warmus, Joseph S., Dilley, Garrett J., Meyers, A. I.

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 183 KB

english, 1993

31

Kinetic isotope effects in the deprotonation of chiral formamidines

Warmus, Joseph S., Rodkin, Mikhail A., Barkley, Robert, Meyers, A. I.

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1993

Language:

english

File:

PDF, 299 KB

english, 1993

32

Design and development of histone deacetylase (HDAC) chemical probes for cell-based profiling

Albrow, Victoria E., Grimley, Rachel L., Clulow, James, Rose, Colin R., Sun, Jianmin, Warmus, Joseph S., Tate, Edward W., Jones, Lyn H., Storer, R. Ian

Journal:

Molecular BioSystems

Year:

2016

Language:

english

File:

PDF, 1.54 MB

english, 2016

33

ChemInform Abstract: Diastereoselective Synthesis of β-Heteroaryl syn-α-Methyl-β-amino Acid Derivatives via a Double Chiral Auxiliary Approach.

Bian, Jianwei, Blakemore, David, Warmus, Joseph S., Sun, Jianmin, Corbett, Matthew, Rose, Colin R., Bechle, Bruce M.

Journal:

Year:

2013

File:

PDF, 100 KB

2013

34

One-Pot Synthesis of α-Branched N -Acylamines via Titanium-Mediated Condensation of Amides, Aldehydes, and Organometallics

Dai, Chunhui, Genovino, Julien, Bechle, Bruce M., Corbett, Matthew S., Huh, Chan Woo, Rose, Colin R., Sun, Jianmin, Warmus, Joseph S., Blakemore, David C.

Journal:

Organic Letters

Year:

2017

Language:

english

File:

PDF, 823 KB

english, 2017

35

Discovery of a series of indazole TRPA1 antagonists

Pryde, David C., Marron, Brian E., West, Christopher W., Reister, Steven, Amato, George, Yoger, Katrina, Antonio, Brett, Padilla, Karen, Cox, Peter J., Turner, Jamie, Warmus, Joseph S, Swain, Nigel Al

Journal:

ACS Medicinal Chemistry Letters

Year:

2017

Language:

english

File:

PDF, 1.08 MB

english, 2017

36

Development of a Scalable Synthetic Route Towards a 2, 2, 6-Trisubstituted Chiral Morpholine via Stereoselective Hydroalkoxylation

Huh, Chan Woo, Bechle, Bruce M., Warmus, Joseph S.

Journal:

Tetrahedron Letters

Year:

2018

Language:

english

File:

PDF, 372 KB

english, 2018

37

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

Sun, Hao, Piotrowski, David W., Orr, Suvi T. M., Warmus, Joseph S., Wolford, Angela C., Coffey, Steven B., Futatsugi, Kentaro, Zhang, Yinsheng, Vaz, Alfin D. N., Leggas, Markos

Journal:

Year:

2018

Language:

english

File:

PDF, 2.21 MB

english, 2018